Electrochemical reduction of substituted pyrimidines in acetonitrile

Synthesis of fully substituted pyrimidines.

A novel approach to the synthesis of fully substituted pyrimidine derivatives armed with an oxy-functionalized acetate chain at the ring is described. The manifold uses amidines as the nitrogen source and activated skipped diynes as the electrophilic reactive partners in a coupled domino strategy. In the first domino reaction, two consecutive aza-Michael additions assemble the six-membered ring...

The biological activity of substituted pyrimidines.

Recent investigations have shown that the animal microorganism, Tetrahymena geleii, requires an exogenous source of pyrimidine for growth (1). This requirement can be met by the addition of cytidylic acid or uracil to the medium (2). Cytosine and thymine are without activity. The failure to utilize the latter two free bases was interpreted as indicating a block in the ability of the organism to...

Effect of Sodium Ions on the Electrochemical Reduction of Diethyl Fumarate in Dimethylsulfoxide and Acetonitrile

Control of the electrochemical reduction of horminone by pH imposition in acetonitrile

An electrochemical study using transient techniques of a quinone-type natural product, horminone, has been performed in acetonitrile in the presence of two buffer solutions of pH = 17.2 and pH = 15.5. Using linear sweep voltammetry, it was found that at both pH values the reduction mechanism of horminone involves a monoelectronic charge-transfer step, followed by a protonation step and homogene...

The electrochemical reduction of a cadmium cryptate on a mercury electrode in acetonitrile

The reduction of the Cd(2,2,2)2+ complex has been studied in acetonitrile using polarography, chronocoulometry, and cyclic voltammetry. The corresponding kinetic parameters have been calculated and are compared with those obtained for the solvated cadmium cation in the same solvent. The study of the eiectrochemical reduction mechanism showed that the final stable products are the free ligand (2...